Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis |
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| Institution: | 1. College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Seoul, Dongdaemun-gu 02447, Republic of Korea;2. Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea;3. Western Seoul Center, Korea Basic Science Institute 150 Bugahyeon-ro, Seoul, Dongdaemun-gu, 03759, Republic of Korea;1. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, 571101, Haikou, PR China;2. Horticultural and Garden College, Hainan University, Haikou 570228, PR China |
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| Abstract: | Two previously unreported spirostanol saponins, dianchonglouosides A and B (1 and 2), along with 7 known steroidal saponins (3–9) were isolated from the rhizomes of Paris polyphylla var. yunnanensis. Their structures were elucidated by extensive spectroscopic analysis (MS, 1D, and 2D NMR), and chemical methods. The cytotoxic activities of the isolated compounds 1–9 were also evaluated against two human cancer cell lines (HEK293 and HepG2). The results showed that compound 7 had the strongest cytotoxic activity against the two cancer cell lines with the IC50 values of 0.6 and 0.9 μM, respectively. |
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| Keywords: | Steroidal saponins Dianchonglouoside A Dianchonglouoside B Cytotoxic activity |
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