Antibacterially active phenolic lipid derivatives from Comarum salesovianum (Steph.) Aschers. et Gr. |
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Institution: | 1. Faculty of Chemistry, University of Warsaw, Pasteura 1, Warsaw 02-093, Poland;2. Centre of New Technologies, University of Warsaw, Banacha 2c, Warsaw 02-097, Poland |
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Abstract: | The antibacterial activity-guided purification of the dichloromethane fraction of the aerial parts of Comarum salesovianum (Steph.) Aschers.et Gr. led to the isolation and elucidation of three phenolic lipid derivatives: 6-(non-8-enyl) salicylic acid (1), 6-nonyl salicylic acid (2) and 3-(non-8-enyl) phenol (3), which were found for the first time in the natural source. The equal mixture of compounds 1 and 2 exhibited potent inhibitory activity against all tested Gram-positive bacterial strains (Enterococcus faecalis, Micrococcus luteus, Staphylococcus epidermidis and Staphylococcus aureus) with inhibitory zones of 12.2–22.1 mm, whereas each single compound showed weaker activity than the mixture of 1 and 2. However, compound 3 strongly inhibited (29.9 ± 1.8) the growth of M. luteus. The presence of salicylic acid with the unsaturated aliphatic side chain is essential for the antibacterial activity strength of phenolic lipid molecules. |
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Keywords: | Phenolic lipid derivatives Antibacterial activity |
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