Regioisomeric acylated polyhydroxy triterpenoids from the stems of Barringtonia racemosa |
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| Affiliation: | 1. Natural Products Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500 607, India;2. NMR Division, Indian Institute of Chemical Technology, Hyderabad 500 607, India;3. Centre for Cellular and Molecular Biology, Hyderabad 500 607, India;1. Department of Environmental Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 3, 30-387 Krakow, Poland;2. Department of Physical Chemistry and Electrochemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland;3. Synchrotron SOLEIL, L’Orme des Merisiers, Saint Aubin, BP48, 91192 Gif sur Yvette Cedex, France;1. Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, Viet nam;2. Cancer Research Laboratory, Vietnam National University, Hochiminh City, Viet nam;1. Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA;2. Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt;1. State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Pharmaceutical Science of Guangxi Normal University, Yucai Road 15, Guilin 541004, Guangxi, PR China;2. Department of Chemistry & Pharmaceutical Science, Guilin Normal College, Xinyi Road 15, Guangxi 541001, PR China |
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| Abstract: | From the stem of Barringtonia racemosa two new regioisomeric oleanane-type triterpenes were isolated and characterized as racemosol B (1) and isoracemosol B (2). The structures were elucidated by the use of spectroscopic methods. In addition, the known compounds lupeol, betulinic acid and bartogenic acid were identified. Racemosol B was evaluated for cytotoxicity against a panel of human tumor cell lines, A-549, MDA-MB-231, HeLa, and K-562 and showed moderate but cell-type selective activity. |
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| Keywords: | Lecythidaceae Acylated triterpenoids Racemosol B Isoracemosol B Cytotoxicity |
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