New acylated triterpene saponins from the roots of Securidaca inappendiculata Hassk |
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| Affiliation: | 1. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China;2. School of Medicine, Nankai University, Tianjin 300072, PR China;3. Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100094, PR China;4. Jiangxi University of Traditional Chinese Medicine, No. 56 Yangmin Road, Nanchang 330006, PR China;1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China;2. Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Germany;3. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China;4. Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China;1. Faculty of Biotechnology Industry, Chengdu University, Chengdu 610106, China;2. School of Basic Medical Sciences & Nursing, Chengdu University, Chengdu 610106, China;3. College of Pharmacy, Dali University, Dali 671000, Yunnan, China;1. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China;2. Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China;3. University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, PR China;4. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China;1. Natural Product Chemistry Laboratory, Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences, 13330 Peace ave., The 4th Building of MAS, Ulaanbaatar, Mongolia;2. Ts. Dash Memorial Laboratory of Bioorganic Chemistry and Pharmacognosy, School of Engineering and Applied Sciences National University of Mongolia, POB-617, Ulaanbaatar 46A, Mongolia;3. Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan |
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| Abstract: | Two new acylated triterpene saponins, named as securioside C (1), securioside D (2), and one pair of isomers 3/4, the (Z)–isomer securioside E (3) being new, together with a known triterpene saponin polygalasaponin XLIV (4) were isolated from the roots of Securidaca inappendiculata Hassk. Their structures were established by HRESIMS, 1D and 2D NMR experiments and comparison of their NMR data with previous reported data. In addition, Compounds 1–2, 3/4, 4 were evaluated for cytotoxicities against LLC (Lewis lung carcinoma) and MCF-7 (human breast cancer) cell lines. Compounds 1 and 2 exhibited moderate cytotoxic activities against LLC cells with IC50 values of 45.56 μM and 85.98 μM. |
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| Keywords: | Polygalaceae Triterpene saponin Cytotoxicity |
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