Three new dinormonoterpenoid glucosides from pericarps of Myriopteron extensum |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;1. Crop Protection Chemicals Division (Organic Chemistry-II), CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India;2. Center for Nuclear Magnetic Resonance, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India;1. Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, PR China;2. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China;3. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA;4. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan;1. Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand;2. Chulabhorn Graduate Institute and Center for Environmental Health and Toxicology (EHT), Kamphaeng Phet 6 Road, Bangkok 10210, Thailand;1. Laboratory of Organic and Bio-Chemistry, Department of the Science for Structures of Matter and Technology, Félix Houphouët Boigny University, Cote d’Ivoire;2. Laboratory of Organic Structural Chemistry, Department of the Science for Structures of Matter and Technology, Félix Houphouët Boigny University, Cote d’Ivoire;3. Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana;4. Laboratory of Galenics, Department of Pharmaceutical Science, Félix Houphouët Boigny University, Cote d’Ivoire;5. Laboratory of Pharmacognosia, CNRS UMR 8076 BioCIS, LabEX LERMIT, Faculty of Pharmacy, Univ. of Paris Sud, France;1. Department of Pharmacognosy, Isfahan University of Medical Sciences, Hezar Jerib Avenue, 73461 Isfahan, Iran;2. Dipartimento di Agraria, Università di Napoli Federico II, Via Università 100, 80055 Portici, Naples, Italy;1. College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China |
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| Abstract: | Three new dinormonoterpenoid glucosides, rel-(3R,4R)-3-(1-hydroxypropan-2-yl)-3,4-epoxypentane-1,5-diol-1-O-β-d-glucopyranoside (1), rel-(3R,4S)-3-(1-hydroxypropan-2-yl)-3,4-epoxypentane-1,5-diol-1-O-β-d-glucopyranoside (2), and rel-(3R,4S)-3-(1-hydroxy-2-propen-2-yl)-3,4-epoxypentane-1,5-diol-1-O-β-d-glucopyranoside (3), were isolated from the edible pericarps of Myriopteron extensum (Wight & Arn.) K. Schum. (Asclepiadaceae). Their structures were elucidated by chemical and spectroscopic methods including HRESIMS, 1D and 2D NMR. Dinormonoterpenoid glucosides were reported from Asclepiadaceae for the first time. Compounds 1–3 were evaluated for their cytotoxicity against five human cancer cell lines HL-60, SMMC-7221, A-549, MCF-7, and SW-480, but they did not exhibit cytotoxicity on the tested cell lines. |
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| Keywords: | Asclepiadaceae Medicinal-edible plant Dinormonoterpenoid glucosides |
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