Two new diphenyl ethers from Acanthopanax senticosus (Rupr. & Maxim.) Harms with PTP1B inhibitory activity |
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| Institution: | 1. College of Pharmacy, Beihua University, Jilin Province 132013, People’s Republic of China;2. Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 363-883, Republic of Korea;3. College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea;1. IJPB, UMR1318 Inra/AgroParisTech, Inra, Route de Saint-Cyr, 78026 Versailles Cedex, France;2. ICMPE, UMR7182, Equipe ESO, 2-8 rue Henri Dunant, 94320 Thiais, France;1. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China;2. Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China;3. University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, PR China;4. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China;1. Faculty of Biotechnology Industry, Chengdu University, Chengdu 610106, China;2. School of Basic Medical Sciences & Nursing, Chengdu University, Chengdu 610106, China;3. College of Pharmacy, Dali University, Dali 671000, Yunnan, China;1. Natural Product Chemistry Laboratory, Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences, 13330 Peace ave., The 4th Building of MAS, Ulaanbaatar, Mongolia;2. Ts. Dash Memorial Laboratory of Bioorganic Chemistry and Pharmacognosy, School of Engineering and Applied Sciences National University of Mongolia, POB-617, Ulaanbaatar 46A, Mongolia;3. Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan |
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| Abstract: | Bioassay-guided fractionation of an EtOAc-soluble extract of Acanthopanax senticosus (Rupr. & Maxim.) Harms yielded two new diphenyl ethers, 3-3′-methoxy-4′-(4″-formyl-2″,6″-dimethoxy-phenoxy)-phenyl]-propenal (1) and 3-3′,5′-dihydroxy-4′-(4″-hydroxymethyl-3″,5″-dimethoxy-phenoxy)-phenyl]-propenal (2), along with eight other known compounds (3–10). The structures of these new ethers were elucidated with spectroscopic and physico-chemical analyses. All of the isolates were evaluated for their in vitro inhibitory activity against PTP1B, VHR and PP1. The new compounds (1 and 2) inhibited PTP1B with IC50 values ranging from 9.2 ± 1.4 to 12.6 ± 1.2 μM. |
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| Keywords: | Maxim ) Harms Araliaceae Diphenyl ethers PTP1B |
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