Antibacterial and anti-phytopathogenic substances from the insect pathogenic fungus Gibellula sp. BCC36964 |
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| Affiliation: | 1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany;2. Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbasia, 11566 Cairo, Egypt;3. Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt;4. Department of Organic Chemistry, University of Debrecen, P. O. B. 400, 4002 Debrecen, Hungary;5. Institut für Physiologische Chemie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Duesbergweg 6, 55128 Mainz, Germany;6. Department of Pharmaceutical Chemistry, College of Pharmacy, Mu’tah University, 61710 Al-Karak, Jordan;1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China;2. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, PR China;3. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, PR China;4. Institute für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany;1. School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, CMU, Rue Michel-Servet 1, 1211 Geneva 4, Switzerland;2. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran |
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| Abstract: | Four new compounds (1–4), which were (−)-(7R)-7-O-methylsydonic acid, gibellulic acid, gibellulins A and B, together with 14 known compounds (5–17 and orcinol) were isolated from the insect pathogenic fungus, Gibellula sp. BCC36964. The chemical structures were elucidated by employing NMR spectroscopic techniques, physico-chemical data, and chemical method. These compounds were evaluated for the biological activities including anti-bacterial, anti-phytopathogenic, anti-Herpes simplex virus-type 1 activities, and cytotoxicity against both cancerous (MCF-7, KB, NCI-H187) and non-cancerous (Vero) cells. |
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| Keywords: | Insect fungus Gibellulins Antibacterial Anti-phytopathogenic |
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