New eudesmane sesquiterpenes from the marine-derived fungus Penicillium thomii |
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| Institution: | 1. G.B Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-Let Vladivostoku 159, Vladivostok 690022, Russian Federation;2. Far Eastern Federal University, Suhanova 8, Vladivostok 690950, Russian Federation;3. Nha Trang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Viet Nam;1. Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Auf''m Hennekamp 65, D-40225 Düsseldorf, Germany;2. MediStatistica, Neuenrade, Germany;3. AstraZeneca R&D, Mölndal, Sweden;4. Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;5. MRC Epidemiology Unit, University of Cambridge, Cambridge, UK;1. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;2. Department of Geology, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan;3. Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan;4. Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan;5. Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan;6. Department of Biotechnology, Sardar Bahadur Khan Women University, Quetta, Pakistan;1. School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenhe District, Shenyang, 110016, China;2. School of Pharmacy, Jilin Medical College, 5 Jilin Street, Fengman District, Jilin, 132013, China;1. State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;2. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;1. Children’s Hospital of Soochow University, Suzhou 215003, China;2. College of Pharmaceutical Science, Soochow University, Suzhou 215123, China;3. National Center for Natural Products Research, and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi 38677, United States |
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| Abstract: | Four new eudesmane-type sesquiterpenes thomimarines A–D (1–4) were isolated from the marine-derived fungus Penicillium thomii. Their structures were established based on spectroscopic methods. The absolute configurations of 1–4 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Inhibitory effects of compounds 1, 2 and 4 on NO production in LPS-induced RAW 264.7 murine macrophages were evaluated. |
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| Keywords: | Sesquiterpenes NO |
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