Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial,acetylcholinesterase inhibitory and cytotoxic activities |
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| Affiliation: | 1. School of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia;2. Faculty of Science and Techonology, Islamic Science University of Malaysia, 71800 Nilai, Malaysia;3. Department of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya, Indonesia;4. Medical Molecular Biology Research Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand Science Park, Pathumthani 12120, Thailand;1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;2. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China;1. Department of Chemistry, South-West University “NeofitRilski”, Blagoevgrad, Bulgaria;2. University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Str., 1756 Sofia, Bulgaria;1. Consiglio per la Ricerca e la Sperimentazione in Agricoltura, Research Unit for Floriculture and Ornamental Species, Corso Inglesi I, 18038 Sanremo, IM, Italy;2. Regional Institute for Floriculture, via Carducci 12 I, 18038 Sanremo, IM, Italy;3. Department of Food Science, University of Napoli Federico II, via Università 100, Portici, NA, Italy;4. DIVAPRA, Agriculture Microbiology and Food Technology, University of Turin, Via Leonardo da Vinci 44, 10095 Grugliasco, TO, Italy;5. Sophia Agrobiotech Institute, UMR INRA, University of Nice, 400 Route des Chappes, BP 167, 06903 Sophia Antipolis Cedex, France;1. Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, 25240 Erzurum, Turkey;2. Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey;3. Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey;1. Pharmacognosie et Molécules Naturelles Bioactives, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;2. Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé, BP 812, Yaoundé, Cameroon;3. Chimie-Biologie Intégrative, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;4. Service Commun d’Analyse, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;5. Laboratoire de Chimie Thérapeutique, UMR 6229, 51 rue Congnacq-Jay, 51100 Reims, France;1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, PR China;2. Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming 650000, PR China |
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| Abstract: | Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S*),12(R*)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 ± 3.7, 16.8 ± 5.4, 16.0 ± 4.2 μg/mL, respectively) and K1 (IC50 values of 16.8 ± 3.1, 14.1 ± 3.7, 11.9 ± 3.3 μg/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities. |
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| Keywords: | Javastemonine A and B Anti-malarial Human acetylcholinesterase Cytotoxicity |
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