Three new sesquiterpenoids from Solanum septemlobum with cytotoxic activities |
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| Affiliation: | 1. School of Pharmaceutical Science, Yantai University, Yantai 264005, People''s Republic of China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, People''s Republic of China;1. Pharmacognosie et Molécules Naturelles Bioactives, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;2. Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé, BP 812, Yaoundé, Cameroon;3. Chimie-Biologie Intégrative, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;4. Service Commun d’Analyse, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;5. Laboratoire de Chimie Thérapeutique, UMR 6229, 51 rue Congnacq-Jay, 51100 Reims, France;1. Argonne National Laboratory, Argonne, IL 60439, USA;2. Los Alamos National Laboratory, Los Alamos, NM 87545, USA;1. School of Pharmacy, Nantong University, Nantong 226001, China;2. School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, China;1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii pr. 31, 119991 Moscow, Russia;2. Lomonosov Moscow State University, Department of Physics, 119991 Moscow, Russia;3. Shubnikov Institute of Crystallography, Russian Academy of Sciences, Leninskii pr. 58, 119333 Moscow, Russia;4. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, 119991 Moscow, Russia;1. Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain;2. College of Materials Science and Engineering, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Laboratory for Biopolymers and Safety Evaluation, Shenzhen University, Shenzhen 518060, PR China;3. Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, PR China;4. Grupo de Investigación “POLímeros: Caracterización y Aplicaciones” (U. A. del ICTP-CSIC), E.T.S.I. Industriales, Universidad Politécnica de Madrid, José Gutiérrez Abascal 2, 28006 Madrid, Spain |
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| Abstract: | Three new sesquiterpenoids, attributable to eudesmane-related (1–2, named septemlobins A–B) and vetispirane-type (3, named septemlobin C), respectively, were isolated from the whole plant of Solanum septemlobum. Their structures were elucidated on the basis of integrated spectroscopic techniques. In vitro, compounds 1–3 were found to show significant cytotoxicities against three cancer cell lines (P-388, HONE-1, and HT-29), and gave IC50 values in the range 3.8–7.5 μM. |
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| Keywords: | Solanaceae Sesquiterpenoid Septemlobins A–C Cytotoxic activity |
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