New bisamide compounds from the bark of Aglaia eximia (Meliaceae) |
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| Affiliation: | 1. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan;2. The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan;3. Green Asia Education Center, Kyushu University, 6-1 Kasuga-koen, Kasuga-city, Fukuoka 816-8580, Japan;4. Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Sendai, Miyagi 980-8578, Japan;5. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, Indonesia;6. Graduate School of Arts and Sciences, Iwate University, Morioka, Iwate 020-8550, Japan |
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| Abstract: | Two new bisamide compounds, eximiamide A (1) and eximiamide B (2) were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of the new compound were elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1 and 2 exhibited cytotoxic activity against P-388 murine leukemia cells with IC50 values of 7.6 and 8.5 μg/mL, respectively. |
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| Keywords: | Exiamiamide A Exiamiamide B Meliaceae Cytotoxic activity |
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