New bioactive derivatives of nonactic acid from the marine Streptomyces griseus derived from the plant Salicornia sp. |
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| Institution: | 1. School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China;2. Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA;3. First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China;4. Qingdao University of Science & Technology, Qingdao 266042, China;1. Bio-Organic Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India;2. Solid State Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India;3. Process Development Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India;1. Bio Organic Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India;2. Fuel Reprocessing Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India;3. Food Technology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India;1. Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, 77840, USA;2. Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India;3. USDA ARS, Southern Plains Agricultural Research Center, College Station, TX, USA;4. Research Area Biochemical Technology, Institute of Chemical and Biological Engineering, TU Wien, 1060, Vienna, Austria;5. Center for Analytical Chemistry, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna (BOKU), Tulln, Austria;1. College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;1. Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin, 150500, PR China;2. Key Laboratory of Microbiology, College of Heilongjiang Province, School of Life Sciences, Heilongjiang University, Harbin, 150080, PR China |
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| Abstract: | Three new compounds, butyl homononactate (5), butyl nonactate (6), 8-actyl homononactic acid (7), along with four known compounds homononactic acids (1), nonactic acid (2), homononactyl nonactate (3), homononactyl homononactate (4) were isolated from the marine Streptomyces griseus RSH0407, derived from the plant Salicornia sp., Chenopodiaceae. Their structures were elucidated by extensive spectroscopic techniques and by comparison with data reported in the literature. The absolute configuration of 3 was first reported by using X-ray copper radiation. Compound 5 exhibited cytotoxic activities against the HCT-8, A2780, BGC-823, BEL-7402, and A549 cell lines in vitro, with IC50 values of 2.87 ± 0.20, 4.90 ± 0.30, 2.19 ± 0.32, 5.07 ± 0.23 and 1.78 ± 0.18 μM, respectively, and compounds 4–7 showed weak antibacterial activities against four bacterials respectively. |
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| Keywords: | Nonactic acid Homononactic acid |
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