Cycloartane glycosides from Astragalus gombo |
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| Affiliation: | 1. Laboratoire de Chimie et Chimie de l’Environnement (L.C.C.E.), Département de Chimie, Faculté des Sciences, Université de Batna, Batna 05000, Algeria;2. USR 3388 CNRS-Pierre Fabre, 3 Avenue Hubert Curien BP 13562, 31035 Toulouse, France;3. Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, BP 1039, 51097 Reims Cedex 2, France;1. School of Life Science, Beijing Institute of Technology, Beijing 100081, PR China;2. Beijing BIT&GY Pharmaceutical R&D Co. Ltd., Beijing 100081, PR China;1. Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, 25240 Erzurum, Turkey;2. Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey;3. Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey;1. School of Pharmacy, Nantong University, Nantong 226001, China;2. School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, China;1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, PR China;2. Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming 650000, PR China;1. Pharmacognosie et Molécules Naturelles Bioactives, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;2. Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé, BP 812, Yaoundé, Cameroon;3. Chimie-Biologie Intégrative, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;4. Service Commun d’Analyse, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;5. Laboratoire de Chimie Thérapeutique, UMR 6229, 51 rue Congnacq-Jay, 51100 Reims, France |
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| Abstract: | Six new cycloartane-type triterpene glycosides named 3-O-[β-d-glucopyranosyl(1 → 2)-β-d-xylopyranosyl]-3β,16β,23(R),24(R),25-pentahydroxycycloartane (1), 3-O-[β-d-glucopyranosyl(1 → 2)-β-d-xylopyranosyl]-3β,16β,23(R),24(R)-tetrahydroxy-25-dehydrocycloartane (2), 3-O-[β-d-xylopyranosyl]-6α-acetoxy-23α-methoxy-16β,23(R)-epoxy-24,25,26,27-tetranorcycloartane (3), 3-O-[β-d-xylopyranosyl]-6α-acetoxy-23α-butoxy-16β,23(R)-epoxy-24,25,26,27-tetranorcycloartane (4), 3-O-[β-d-glucopyranosyl(1 → 2)]-β-d-xylopyranosyl]-6α-acetoxy-23α-methoxy-16β,23(R)-epoxy-24,25,26,27-tetranorcycloartane (5), 3-O-[β-d-glucopyranosyl(1 → 2)]-β-d-xylopyranosyl]-23α-methoxy-16β,23(R)-epoxy-4,25,26,27-tetranorcycloartane (6), in addition to three known secondary metabolites consisting of another cycloartane triterpene glycoside and two flavonol glycosides, were isolated from the aerial parts of Astragalus gombo Coss. & Dur. (Fabaceae). The structures of the isolated compounds were established by spectroscopic methods, including 1D and 2D-NMR, mass spectrometry and comparison with literature data. |
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| Keywords: | Fabaceae Cycloartane glycosides NMR |
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