Resistance exercise training increase activation of AKT-eNOS and Ref-1 expression by FOXO-1 activation in aorta of F344 rats |
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| Authors: | Meng Li Wei Li Jin-Hwan Yoon Byeong Hwa Jeon Sang Ki Lee |
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| Institution: | 1.Department of Sports Science, Chungnam National University, Daejeon, Republic of Korea;2.Department of Sports Science, Hannam University, Daejeon, Republic of Korea;3.Department of physiology, Chungnam National University, Deajeon, Republic of Korea |
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| Abstract: | PurposeThis study investigated the effects of resistance exercise on the Akt-eNOS, the activation of antioxidant protein and FOXO1 in the aorta of F344 rats.MethodsMale 7 week-old F344 rats were randomly divided into 2 groups: a climbing group (n = 6) and a sedentary group (n = 6). H&E staining and western blotting were used to analyze the rat aortas and target proteins.ResultsResistance exercise training did not significantly affect aortic structure. Phosphorylation of AKT and eNOS and expression of MnSOD and Ref-1 were significantly increased while FOXO1 phosphorylation was significantly decreased in the resistance exercise group compared with the sedentary group.ConclusionWe demonstrate that resistance exercise activates the Akt-eNOS and Ref-1 protein without changes to aortic thickness via FOXO-1 activation in the aorta of F344 rats. |
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| Keywords: | resistance exercise aorta structure FOXO1 oxidative stress MnSOD Ref-1 |
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