糖尿病性勃起功能障碍与抑郁症的共病研究

目的:观察糖尿病性勃起功能障碍(diabetic erectile dysfunction,DMED)和抑郁症的共病情况,分析相关的影响因素,探讨抑郁症对DMED的影响。方法:将500例糖尿病男性患者进行勃起障碍评估和抑郁评分,将筛选出的DMED患者分为抑郁症组和无抑郁症组,记录患者的年龄、病程、血压、血糖、糖化血红蛋白、血脂、C肽、睾酮(T)、催乳素(PRL)及雌二醇(E2)等信息。DMED并发抑郁症的相关危险因素分析采用logistic回归分析。结果:DMED和抑郁症的共病率为73%,DMED患者的抑郁量表指数高。单因素logistic回归显示年龄、病程、体质量指数(BMI)、血糖、糖化血红蛋白、血脂、激素水平是DMED并发抑郁症的影响因素;多因素logistic回归分析表明年龄、病程、睾酮水平是DMED并发抑郁症的影响因素。结论:DMED患者和抑郁症的共病率较高,年龄、病程和睾酮水平可能是DMED和抑郁症共同的影响因素。

The Research of Comorbidity with Diabetic ErectiIe Dysfunction and Depression

Objective:To study the comorbid conditions and influencing factors of diabetic patients with ED and depression, and observe the effects of depression on DMED.Methods:Erectile function and depression scores were evaluated in 500 cases of male diabetic patients. DMED patients were divided into the depression group and non-depression group. The age, course of disease, blood pressure, blood glucose, glycosylated hemoglobin, blood lipid, and C-peptide, serum testosterone(T), prolactin (PRL) and estradiol (E2) levels were recorded. Logistic regression analysis was used to analyze the related risk factors for DMED concurrent depression.Results:DMED and depression comorbidity rate was 73%, DMED concurrent depression scale index was high. Single factor logistic regression analysis showed average age, course of disease, body mass index (BMI), blood glucose, glycosylated hemoglobin, blood lipid, hormone level were the influencing factors of DMED concurrent depression, while multiariable logistic regression equation suggested age, course of disease, serum testosterone level were the influencing factors of DMED concurrent depression.Conclusion:The comorbidity rate of DMED and depression was high, age, course of disease, serum testosterone level were the influence factors of diabetic ED and depression.