法舒地尔对单纯急性心肌梗死大鼠心肌形态学、心肌酶学及血液流变学的影响

目的:探讨法舒地尔对单纯急性心肌梗死模型大鼠心肌形态学、心肌酶学及血液流变学变化的影响。方法:将40只Wistar大鼠分为空白组、假手术组、治疗组和模型组。治疗组给予法舒地尔0.01 m L/g,股静脉注射,其余各组给予生理盐水。治疗结束后检测各组大鼠心肌形态学、心肌酶学及血液流变学各指标。结果:与其余各组相比,治疗组大鼠各指标均显著改善,空白组与假手术组各指标水平无显著差异(P0.05),治疗组具体表现为:CK、LDH、ASH水平明显降低(P0.05);PAR、PAG水平均明显改善,与模型组相比明显降低;HCT、ESR水平明显降低(P0.05);MIS水平明显下降(P0.05)。结论:法舒地尔能够明显改善单纯急性心肌梗死模型大鼠的心肌形态学、心肌酶学及血液流变学各指标,对临床有指导意义。

Effect of Myocardial Morphology, Myocardial Enzymes and Blood Rheologyon Acute Myocardial Infarction Rat Model by Fasudil

Objective:To investigate the effects of fasudil on the changes of myocardial morphology, myocardial enzymes andblood rheology of rats with acute myocardial infarction.Methods:40 Wistar rats were divided into the control group, sham operationgroup, treatment group and model group. The treatment group was given fasudil 0.01 mL/g, injected into the femoral vein, the rest of thegroup were given normal saline. Then the myocardial morphology, myocardial enzymes and blood rheology in the four groups weredetected and compared.Results:There was no significant difference about the levels of each index in control group and sham operationgroup (P>0.05); The indexes of rats in the treatment group were significantly improved compared with other groups, the treatment groupspecific performance: CK, LDH, ASH levels were significantly lower (P<0.05); PAR, PAG levels were significantly improved (P<0.05);HCT, ESR levels were significantly lower (P<0.05); The level of MIS decreased significantly (P<0.05).Conclusion:Fasudil can improvethe myocardial morphology, myocardial enzymes and blood rheology indexes of the model rats with simple acute myocardial infarctionwhich has the significance to the clinical.