软骨寡聚基质蛋白在关节炎中的作用

研究表明在骨性关节炎和类风湿性关节炎患者血清中软骨寡聚基质蛋白(cartilage oligomeric matrix protein,COMP)可以在出现关节形态学改变以前就在生化代谢方面表现异常,为早期诊断提供了新思路,其可以作为反映早期关节软骨破坏和骨关节疾病急性活动程度的指标。从而能在病变不可逆发展之前及早防治,逆转或延缓病变进展。COMP是关节炎疾病的诊断与判断疾病进展和缓解潜在生物学标志物。本文就软骨寡聚基质蛋白及其在关节炎中的作用作一综述。

Recent Advances in Cartilage Oligomeric Matrix Protein and Arthritis

Studies have shown that in the serum of patients with osteoarthritis and rheumatoid arthritis in the joints COMP morphologicalchanges can occur before the performance in terms of biochemical metabolic abnormalities. It cloud be used for the early diagnosisas a new idea, which can serve as a reflection of acute articular cartilage damage and early indicators of the level of activity of boneand joint diseases. Thus early prevention, reverse or slow disease progression before irreversible lesions develop. COMP is a diagnosisand determine the progress and mitigate potential biomarkers of disease arthritis disease. This paper reviews on cartilage oligomeric matrixprotein and its role in arthritis.