痰湿体质PCOS临床特征及T淋巴细胞亚群分布特征分析

目的:探讨痰湿体质多囊卵巢综合征患者临床特征及T淋巴细胞亚群分布特征。方法:根据PCOS鹿特丹诊断标准和王琦教授痰湿体质的判定标准,选择痰湿体质PCOS患者、非痰湿体质PCOS患者各30例,正常对照组15例进行性激素和糖脂代谢指标检测和T淋巴细胞亚群检测,明确痰湿体质PCOS患者临床特征及T淋巴细胞亚群的分布特征。结果:三组在年龄和体重指数上无差异,具有可比性;痰湿体质PCOS与非痰湿体质PCOS在LH、T、30 min INS、120 min INS、CHO、LDL水平明显高于对照组,具有统计学意义(P0.05);痰湿体质组OGTT血糖水平、CHO、LDL、IR水平明显高于非痰湿体质组,差异具有统计学意义(P0.05)。痰湿体质、非痰湿体质PCOS患者外周血CD4+T淋巴细胞、CD4+/CD8+明显高于对照组,且痰湿体质PCOS患者CD4+T淋巴细胞、CD4+/CD8+明显高于非痰湿体质PCOS患者,差异有显著性(P0.05)。结论:PCOS患者存在糖脂代谢紊乱,其中痰湿体质患者较非痰湿体质患者更明显;PCOS患者存在细胞免疫异常,痰湿体质患者较非痰湿体质患者更易出现T淋巴细胞亚群异常,说明痰湿体质PCOS的发生与免疫因素关系更密切。

Analysis of the Clinical Features and T Lymphocyte Subsets Distribution on PhlegmDampness Polycystic Ovary Syndrome Patients

Objective:To explore the clinical features and distribution of T lymphocyte subsets in the patient with phlegm dampness of polycystic ovary syndrome:Methods:According to the criteria of diagnosis standard of Rotterdam PCOS and Professor Wang Qi phlegm constitution, 30 cases of phlegm dampness patients with PCOS and 30 cases of non-phlegm dampness patients with PCOS and 15 cases of normal control were selected. The level of sex hormone and glucose and lipid metabolism and the distribution of T lymphocyte subsets and the distribution characteristic of T lymphocyte subsets was detected, and the clinical features of phlegm dampness patients with PCOS was analyzed.Results:There was no difference in age and body mass index during the three groups. The level of LH, T, INS 30 min, INS 120 min, CHO, LDL in phlegm dampness and non-phlegm dampness PCOS groups was increased significantly with statistical significance compared with control group (P<0.05). The level of glucose of OGTT, CHO, LDL, IR in phlegm dampness PCOS groups was higher than that of non-phlegm dampness PCOS groups. CD4+T lymphocyte, CD4+/CD8+ in both PCOS groups was increased significantly in compared with control group, more obviously in phlegm dampness PCOS groups than non-phlegm dampness patients with PCOS(P<0.05).Conclusion:There was glucose and lipid metabolic disorder and cellular immune abnormality in patients with PCOS, and it was more obvious in the patients with phlegm dampness compared with non phlegm dampness constitution, suggesting that the pathogenesis of PCOS with phlegmdampness constitution are closely related to the immune factors.