Arsenic trioxide induces gallbladder carcinoma cell apoptosis via downregulation of Bcl-2 |
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Authors: | Ai Zhilong Lu Weiqi Qin Xinyu |
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Institution: | Zhongshan Hospital, Fudan University, Shanghai 200032, People's Republic of China. |
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Abstract: | Gallbladder carcinoma (GBC), an aggressive and mostly lethal malignancy, is known to be resistant to a number of apoptotic stimuli. Here, we report for the first time the pro-apoptosis role of arsenic trioxide (As2O3) in gallbladder carcinoma and identify the contribution of Bcl-2 in the As2O3-induced apoptosis. The treatment of As2O3 in gallbladder carcinoma cells could induce apoptosis in a dose-dependent manner and downregulate the expression of anti-apoptotic protein Bcl-2 at mRNA level. Moreover, Bcl-2 overexpression could protect gallbladder carcinoma cells from As2O3-induced apoptosis, indicating the contribution of Bcl-2 in As2O3-induced apoptosis. Taken together, these results suggest that arsenic trioxide induces gallbladder carcinoma cell apoptosis via downregulation of Bcl-2, which may have important therapeutic implications in gallbladder carcinoma patients. |
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Keywords: | Gallbladder carcinoma Arsenic trioxide Apoptosis AKT Bcl-2 In vitro |
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