Inhibitors of the serotonin transporter protein (SERT): the design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indoles. High-affinity serotonergic ligands for conjugation with quantum dots |
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Authors: | Tomlinson Ian D Mason John N Blakely Randy D Rosenthal Sandra J |
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Institution: | The Department of Chemistry, Vanderbilt University, Station B, 351822, Nashville, TN 37235-1822, USA. |
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Abstract: | There is a growing demand for compounds with specificity for the serotonin transporter protein (SERT) that can be conjugated to cadmium selenide/zinc sulfide core shell nanocrystals. This letter describes the design and synthesis of two different biotinylated SERT antagonists that can be attached to streptavidin-coated cadmium selenide/zinc sulfide core shell nanocrystals. |
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