Centrally administered N-terminal fragments of ACTH (1-10, 4-10, 4-9) display convulsant properties in rabbits |
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Authors: | A Tartara P Bo M Maurelli F Savoldi |
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Institution: | 1. Epilepsy Center, Neurologic Clinic, Italy;2. Neurologic Clinic of the University of Pavia, Italy |
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Abstract: | Electroencephalographic and behavioral effects of the following ACTH fragments: 1-4, 4-9, 4-11, 1-10, 4-10, 1-13, 1-17 and 1-24 were studied in rabbits. Sequences 4-9, 1-10 and 4-10 displayed some epileptic properties, i.e., they induced epileptic seizures (only electrographic or also behavioral) or increased hippocampal spiking. The 4-9 sequence seemed to be the common sequence responsible for these proconvulsant effects. The possible involvement of the enkephalinergic system is discussed. |
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Keywords: | ACTH 1–10 4–9 4–10 EEG Epilepsy Rabbit |
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