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DNA Polymorphism of the major histocompatibility class I genes and their association with serologically defined haplotypes |
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| Authors: | A. J. Driesel K. Römer F. Schunter M. D. Laryea E. M. Schneider P. Wernet J. Henke M. Basler J. Kömpf |
| Affiliation: | (1) Present address: Institut für Humangenetik und Anthropologie, Universität Düsseldorf, Universitätsstraße 1, 23.12, 4000 Gebäude, Düsseldorf, Germany;(2) Abteilung für Transfusionswesen, Universität Tübingen, Tübingen, Germany;(3) Immunologie Labor, Medizinische Universität Klinik, Abteilung II, Tübingen, Germany;(4) Institut für Rechtsmedizin, Universität Düsseldorf, Düsseldorf, Germany;(5) Institut für Rechtsmedizin, Freie Universität Berlin, Berlin, Germany;(6) Institut für Anthropologie und Humangenetik, Universität Tübingen, Tübingen, Germany |
| Abstract: | DNA of unrelated persons as well as members of families that were totally or partially homozygous or completely heterozygous on the loci of the major histocompatibility class I genes has been isolated from peripheral blood lymphocytes and blot hybridized with the class I pseudogene pHLA 12.4 probe. The autoradiographic DNA patterns were discussed and compared with well-defined serological features. Positive associations with serologically typed alleles had been demonstrated for HLA-A1,11 ; -A2; -A3; -B7; -B14; -B35;-Bw41; and -Cw5. |
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