Reversal of the changes in DNA and chromosome structure which follow the inhibition of UV-induced repair in human cells |
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Authors: | R T Johnson A R Collins |
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Affiliation: | Department of Zoology, University of Cambridge, Downing St., Cambridge, CB2 3EJ, U.K. |
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Abstract: | The inhibition of UV-induced repair DNA synthesis by hydroxyurea, deoxyadenosine or 1-β-D-arabinofuranosylcytosine is reflected in changes in chromosome appearance (decondensation seen in fixed preparations) and DNA structure (accumulation of unwinding points or single-strand gaps). These changes are rapidly reversed if the inhibition is neutralised by addition of precursors of DNA synthesis. The organisation of chromosomes apparently survives the prolonged presence of substantial DNA breakage. |
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