Studies on themodulation of immunoglobulin production by prostaglandins |
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| Authors: | T. Morito A.D. Bankhurst R.C. Williams |
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| Affiliation: | Department of Medicine University of New Mexico School of Medicine Albuquerque, New Mexico 87131, USA |
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| Abstract: | The present study investigated the effect of prostaglandins (PG) on the in vitro production of polyclonal IgG and IgM by pokeweed mitogen- stimulated normal human peripheral mononuclear cells. Concentrations of PGE1 and PGA1 in excess of 10−6M were suppressive. PGE2 and PGs of the F series were less effective and significant suppression was seen in concentrations greater than 10−3M. Indomethacin added to cell cultures did not enhance Ig production. This discrepancy between physiologic PG concentrations and the very large pharmacologic concentration necessary to suppress Ig synthesis in vitro makes the physiologic role of PG in the modulation of Ig synthesis questionable. |
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