Substance P-containing nerve fibres in large peripheral blood vessels of the rat |
| |
Authors: | F Barja R Mathison H Huggel |
| |
Institution: | 1. Department of Animal Biology, University of Geneva, Geneva, Switzerland
|
| |
Abstract: | Substance P-immunoreactive nerve fibres were localized by the indirect immunohistochemical method in the adventitia and the adventitial-medial border of large peripheral arteries and veins of the rat. Arteries showed a richer substance P-containing innervation than veins. The superior mesenteric artery was densely innervated, whereas no substance P-containing fibres were found around the carotid artery. Substance P produced a vasoconstriction of the veins, but was basically without effect on arteries, although with the carotid artery a dose-dependent relaxation was observed. The absence of a correlation between the degree of innervation of the blood vessels and their responsiveness to exogenous substance P suggests that there nerves do not subserve a vasomotor function. The depletion of substance P immunoreactivity from nerves in arteries and veins by capsaicin suggest that substance P-containing vascular nerves are primarily sensory in nature. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|