<Emphasis Type="Italic">Drosophila mitoferrin</Emphasis>is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis |
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Authors: | Christoph Metzendorf Maria I Lind |
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Institution: | 1.Comparative Physiology,Uppsala University,Uppsala,Sweden |
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Abstract: | Background Mammals and Drosophila melanogaster share some striking similarities in spermatogenesis. Mitochondria in spermatids undergo dramatic morphological changes and
syncytial spermatids are stripped from their cytoplasm and then individually wrapped by single membranes in an individualization
process. In mammalian and fruit fly testis, components of the mitochondrial iron metabolism are expressed, but so far their
function during spermatogenesis is unknown. Here we investigate the role of Drosophila mitoferrin (dmfrn), which is a mitochondrial carrier protein with an established role in the mitochondrial iron metabolism,
during spermatogenesis. |
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