Inositol phosphates turnover, cytosolic Ca++ and pH: putative signals for the control of cell growth |
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| Authors: | L M Vicentini M L Villereal |
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| Institution: | 1. Department of Pharmacological and Physiological Sciences, University of Chicago, Chicago, USA;1. National Glycoengineering Research Center, and Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Jinan, 250100, China;2. Shandong Provincial Key Laboratory of Biomedical Polymers, Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China;3. Department of Vascular Surgery, Qilu Hospital, Shandong University, Jinan, 250100, China;1. Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 406-772, South Korea;2. Department of Nano-Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 406-772, South Korea;3. Division of Life Sciences and Bio-Resource and Environmental Center, Incheon National University, Incheon, 406-772, South Korea;1. Beijing Key Laboratory of Advanced Functional Polymer Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China;2. School of Materials Science & Engineering (Blk N4.1), Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore;3. Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China;1. Walther-Straub-Institute of Pharmacology and Toxicology, Member of the German Center for Lung Research (DZL), LMU Munich, Germany;2. Bundeswehr-Institute of Pharmacology and Toxicology, Munich, Germany;1. School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China;2. School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China;3. Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan;4. Institute of Natural Sciences, MoE-LSC and CMA-Shanghai, Shanghai Jiao Tong University, Shanghai 200240, China;1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi''an, 710069, China;2. MOE Key Laboratory of Bioinformatics, Center for Synthetic and System Biology, Tsinghua University, Beijing, 100084, China;3. School of Life Sciences, Tsinghua University, Beijing, 100084, China;4. State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China;5. Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China |
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| Abstract: | The signals that induce a cell to divide are usually external and in the form of a binding of growth factors. We focussed our attention in defining the sequence of events which occurs after the binding of the mitogens to their surface receptors. One of the early membrane events stimulated by growth factors is a Na+ flux coupled to a H+ efflux that is typically inhibited by amiloride. The importance of this event and of the consequent cytoplasmic alkalinization for the cell proliferation is discussed. Recent data indicate that mitogens increase intracellular Ca++ levels and activate protein kinase C by inducing the hydrolysis of membrane phosphoinositides. A role for Ca++ and protein kinase C in activating Na+/H+ A role for Ca++ and protein kinase C in activating Na+/H+ exchange system is discussed. Finally a model is presented that illustrates the first membrane events stimulated by the growth factors. The model reveals an intimate interconnections between phosphoinositide metabolism, cytosolic Ca++ rise, protein kinase C and cytoplasmic alkalinization. |
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