| 四数九里香中的咔唑类生物碱成分及其细胞毒活性研究 |
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| 引用本文： | 周永福,陈鸿平,陈林,刘友平,李应. 四数九里香中的咔唑类生物碱成分及其细胞毒活性研究[J]. 天然产物研究与开发, 2019, 0(2): 269-272,305 |
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| 作者姓名： | 周永福 陈鸿平 陈林 刘友平 李应 |
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| 作者单位： | 成都中医药大学药学院;重庆工业职业技术学院化学与制药工程学院 |
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| 基金项目： | 重庆市教育委员会科学技术研究计划青年项目(KJ1603006) |
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| 摘 要： | 为阐明民族药四数九里香Murraya tetramera Huang的药效物质基础,本研究使用色谱分离技术从其醇提取物中分离纯化得7个咔唑类生物碱和1个甾体类化合物,运用波谱方法鉴定为β-谷甾醇(1)、1-甲基-3-丙酰基咔唑(2)、1-甲氧基-3-乙基咔唑(3)、1-甲氧基-3-甲酰基咔唑(4)、1-甲氧基-3-甲基咔唑(5)、1-羧基甲酯-3-甲基咔唑(6)、1-羧基甲酯-3-乙基咔唑(7)、mananimbine(8)。除了化合物1,其他化合物为首次从该植物中分离得到;化合物2～5、7对SMMC-7721的IC50分别为40. 93±0. 66、46. 03±2. 05、114. 21±5. 67、15. 79±0. 99、185. 1±0. 44。结果表明化合物2～5、7对SMMC-7721显现很好的细胞毒活性。
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| 关 键 词： | 四数九里香 民族民间药 咔唑生物碱 细胞毒活性 核磁共振 |
Carbazole alkaloids from Murraya tetramera Huang and their cytotoxic activity |
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| ZHOU Yong-fu,CHEN Hong-ping,CHEN lin,LIU You-ping,LI Ying. Carbazole alkaloids from Murraya tetramera Huang and their cytotoxic activity[J]. Natural Product Research and Development, 2019, 0(2): 269-272,305 |
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| Authors: | ZHOU Yong-fu CHEN Hong-ping CHEN lin LIU You-ping LI Ying |
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| Affiliation: | (China;ChongQing Industry Polytechnic College,Chonging 401120) |
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| Abstract: | The Carbazole alkaloids from Murraya tetramera Huang and their cytotoxic activities were investigated in this study.The ethanol extract from Murraya tetramera Huang were separated by chromatographic techniques.The structures of these compounds were identified by 1H NMR,3C NMR,HSQC,HMBC.they wereβ-sitosterol(1),1-methyl-3-propionylcarbazole(2),1-methoxy-3-ethylCarbazole(3),1-methoxy-3-formylcarbazole(4),1-methoxy-3-methylcarbazole(5),1-carboxymethylester-3-methylcarbazole(6),1-carboxymethylester-3-ethylcar-bazole(7),manembine(8).All of these compounds were isolated from this plant for the first time except compound(1).The IC50 of compound 2,3,4,5,and 7 against SMMC-7721 was 40.93±0.66,46.03±2.05,114.21±5.67,15.79±0.99 and 185.1±0.44,respectively.The compound(2),(3),(4),(5),(7),showed good cytotoxic activities against SMMC-7721. |
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| Keywords: | Murraya tetramera Huang folk medicine carbazole alkaloids cytotoxic activity NMR |
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