| 人参皂苷活性单体-20(R)-人参皂苷Rg3药理作用及其机制的研究进展 |
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| 引用本文： | 陈德云,沈志强,何波. 人参皂苷活性单体-20(R)-人参皂苷Rg3药理作用及其机制的研究进展[J]. 天然产物研究与开发, 2019, 0(7): 1285-1290 |
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| 作者姓名： | 陈德云 沈志强 何波 |
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| 作者单位： | 昆明医科大学药学院暨云南省天然药物药理重点实验室 |
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| 基金项目： | 国家自然科学基金(81441129,81660613,81860665);云南省应用基础研究-昆医联合专项(2013FZ268);昆明医科大学“百名中青年学术和技术骨干”培养计划(60117190442) |
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| 摘 要： | 20(R)-人参皂苷Rg3是人参皂苷的主要活性单体之一,主要用于抗肿瘤治疗。近年来,20(R)-人参皂苷Rg3的药理作用不断取得进展,其中保护心脑血管、增强免疫功能、抗增生性瘢痕、抗疲劳的药理作用尤为值得关注。本文整理近年来国内外与20(R)-人参皂苷Rg3相关文献,论述其主要药理作用及其作用机制,为进一步开发20(R)-人参皂苷Rg3提供了科学依据。
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| 关 键 词： | 20(R)-人参皂苷Rg3 皂苷单体 药理作用 作用机制 |
Advances in the research of pharmacological effects and its mechanisms of 20(R)-ginsenoside Rg3 |
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| CHEN De-yun,SHEN Zhi-qiang,HE Bo. Advances in the research of pharmacological effects and its mechanisms of 20(R)-ginsenoside Rg3[J]. Natural Product Research and Development, 2019, 0(7): 1285-1290 |
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| Authors: | CHEN De-yun SHEN Zhi-qiang HE Bo |
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| Affiliation: | (School of Pharmaceutical Science & Yunnan Key Laboratory ofPharmacology for Natural Products,Kunming Medical University, 650500 ,China) |
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| Abstract: | 20(R)-ginsenoside Rg3 was one of the major active components of ginseng saponins and was mainly used in anti-tumor therapy.In recent years,the pharmacological effects of 20(R)-ginsenoside Rg3 had made continuous progress.It was important to pay attention to the pharmacological effects of 20(R)-ginsenoside Rg3,especially the protective effects on cardio-cerebrovascular diseases,immune function enhancement,anti-hypertrophic scar and anti-fatigue activities.In this article,we summarized the relevant literature on 20(R)-ginsenoside Rg3 at home and abroad,and discussed its pharmacological effects and molecular mechanisms,which provided a scientific basis for the further research. |
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| Keywords: | 20(R)-ginsenoside Rg3 saponins monomer pharmacologic effects molecular mechanisms |
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