Heterogeneous structure of O-antigenic part of lipopolysaccharide of <Emphasis Type="Italic">Salmonella</Emphasis> telaviv (Serogroup O:28) containing 3-acetamido-3,6-dideoxy-D-glucopyranose |
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Authors: | J Kumirska H Dziadziuszko M Czerwicka E A Lubecka D Kunikowska E M Siedlecka P Stepnowski |
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Institution: | Department of Chemistry, University of Gdańsk, Sobieskiego, Poland. kumirska@chem.univ.gda.pl |
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Abstract: | The O-polysaccharide of Salmonella Telaviv was obtained by mild acid degradation of the lipopolysaccharide and studied by chemical methods (sugar and methylation
analyses, Smith degradation, de-O-acetylation) and NMR spectroscopy. The structure of the O-polysaccharide was established. The repeating units that are proximal
to the lipopolysaccharide core region mostly have a digalactose side chain and lack glucose, whereas those at the other end
of the chain mostly do bear glucose but are devoid of the disaccharide side chain. This is the first structure established
for the O-polysaccharide of a Salmonella serogroup O:28 (formerly M) strain characterized by subfactors O281 and O282. Knowledge of this structure and the structure of the O-polysaccharide of Salmonella Dakar (O281, O283) established earlier is crucial for determination of the exact structures associated with subfactors O281, O282, and O283 and elucidation of the genetic basis of the close relationship between Escherichia coli O71 and S. enterica O:28 O-antigens. |
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