Pro-necrotic Activity of Cationic Mastoparan Peptides in Human Glioblastoma Multiforme Cells Via Membranolytic Action |
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Authors: | Annielle Mendes Brito da Silva Laíz Costa Silva-Gonçalves Fernando Augusto Oliveira Manoel Arcisio-Miranda |
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Affiliation: | 1.Laboratório de Neurobiologia Estrutural e Funcional (LaNEF), Departamento de Biofísica, Escola Paulista de Medicina,Universidade Federal de S?o Paulo (Unifesp),S?o Paulo,Brazil;2.Laboratório de Neurobiologia Celular e Molecular (LaNeC), Centro de Matemática, Computa??o e Cogni??o,Universidade Federal do ABC (UFABC),S?o Paulo,Brazil |
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Abstract: | Glioblastoma multiforme is the most common and lethal malignant brain tumor. Because of its complexity and heterogeneity, this tumor has become resistant to conventional therapies and the available treatment produces multiple side effects. Here, using multiple experimental approaches, we demonstrate that three mastoparan peptides—Polybia-MP1, Mastoparan X, and HR1—from solitary wasp venom exhibit potent anticancer activity toward human glioblastoma multiforme cells. Importantly, the antiglioblastoma action of mastoparan peptides occurs by membranolytic activity, leading to necrosis. Our data also suggest a direct relation between mastoparan membranolytic potency and the presence of negatively charged phospholipids like phosphatidylserine. Collectively, these data may warrant additional studies for mastoparan peptides as new agents for the treatment of glioblastoma multiforme brain tumor. |
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