Experimental modification of structures at the periphery of the liver cell nucleus

Summary This paper deals with the morphological effects of various experimental treatments on structures at the periphery of isolated liver cell nuclei. The results demonstrate that the outer and inner nuclear membranes, the pore-annulus complex, the fibrous lamina, and the perinuclear chromatin layer are interconnected, and together constitute an integrated cortex surrounding the nucleus in these interphase cells. Treatment with Triton X100 removes both the outer and inner nuclear membranes.Work supported by the U. S. Atomic Energy Commission.This work was started before the death of Dr. Wassermann on June 16, 1969; this paper is respectfully dedicated to his memory.