基于RNA的抗HIV-1基因治疗方法研究进展

艾滋病自发现以来在全球范围内迅速蔓延,危害性极高,目前广泛采用的高效抗逆转录病毒疗法(HAART)虽能够显著提高HIV-1感染者生活质量,但存在着价格昂贵,耐药和副作用的问题经常会导致HAART治疗的中断。要获得长期持续的抗病毒治疗效果还有待于研发新的抗病毒药物和治疗方法。近年来随着分子生物技术、干细胞研究、纳米技术等相关技术的发展,关于抗HIV-1基因治疗方法的研究受到了广泛关注。主要针对基于RNA的抗HIV-1基因治疗方法,包括反义RNA、核酶、RNA诱饵以及RNA干扰技术在抗HIV-1基因治疗方面进行综述。研究表明,以RNA为基础的抗HIV-1基因治疗方法有望成为传统治疗方法的一种有效辅助手段。

Current Development on RNA-based Anti-HIV-1 Gene Therapy

Acquired immune deficiency syndrome(AIDS) is a high-risk disease which spreads rapidly all over the world since it has been discovered.Although the highly active antiretroviral therapy(HAART) that are widely used in present can improve the quality of life of HIV-1 infected patient dramatically,treatment interruptions have often occurred because of the high cost,drug resistance and side effects.As a result,the new antiretroviral drugs and approaches are demanded for sustained antiretrovial effects.With the development of molecular biology,stem cell,nanotechnology and other related technology,gene therapy for HIV-1 infection has attracted considerable attention in recent years.RNA-based gene therapy for treatment of HIV-1 infection,including antisense RNA,ribozymes,RNA decoys and the RNA interference are focused on.These studies demonstrated that the RNA-based anti-HIV-1 gene therapy may serve as an effective adjuvant to traditional treatments.