肿瘤血管生成的实验模型

血管生成在肿瘤的生长、侵袭和转移中起着重要的作用。通过抑制新生血管的形成和发展来达到杀伤肿瘤细胞的目的,是一种确实有效的"饥饿"疗法。近年来对抗血管生成治疗肿瘤的研究取得了很大的进展,目前已建立了多种实验模型和评价标准,包括体内和体外两大类。每种模型都有其优缺点,可根据研究内容选择合适、有效的实验模型。

Models of Tumor Angiogenesis Assay

Angiogenesis plays a key role in tumor growth,invasion and metastasis.The tumors will die of ex haustion by cutting off the tumor angiogenesis.Anti-angiogenesis therapy is considered a promising approach and a breakthrough in cancer therapy.Most studies of angiogenesis inhibitors rely on various models and evaluation cri teria,both in vitro and in vivo.Each model has its own unique characteristics and limits.The appropriate and ef fective models can be selected according to the study.