| 甲胎蛋白衍生肽作为抗原表位在肝癌免疫治疗中的作用 |
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| 引用本文： | 冯玥,蓝兴国,李玉花. 甲胎蛋白衍生肽作为抗原表位在肝癌免疫治疗中的作用[J]. 生物技术通讯, 2012, 23(4): 601-603 |
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| 作者姓名： | 冯玥 蓝兴国 李玉花 |
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| 作者单位： | 1. 东北林业大学生命科学学院 黑龙江哈尔滨 150040;大庆麦伯康生物技术有限公司,黑龙江大庆 163316
2. 东北林业大学生命科学学院 黑龙江哈尔滨 150040 |
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| 基金项目： | 黑龙江省发展高新技术产业专项(FW11C201);大庆市科技计划(scyc-2010-62);大庆高新区科技专项(DQGX10ZS005) |
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| 摘 要： | 甲胎蛋白(AFP)作为一种肝癌诊断的标志物,一直受到人们的广泛关注。通过对AFP衍生肽的研究,已经发现AFP衍生肽作为抗原表位在肝癌的生长和发展过程中对T细胞有刺激作用。我们通过阐述AFP衍生肽抗原表位的分布及其对肝细胞癌中T细胞活动的影响,进一步说明AFP衍生肽作为抗原表位在肝癌免疫治疗中的作用。
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| 关 键 词： | 甲胎蛋白 衍生肽 抗原表位 肝癌 免疫治疗 |
Alpha-Fetoprotein Derived Peptides as Epitopes for Hepatoma Im munotherapy |
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| FENG Yue , LAN Xing-Guo , LI Yu-Hua. Alpha-Fetoprotein Derived Peptides as Epitopes for Hepatoma Im munotherapy[J]. Letters in Biotechnology, 2012, 23(4): 601-603 |
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| Authors: | FENG Yue LAN Xing-Guo LI Yu-Hua |
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| Affiliation: | 1* 1.College of Life Sciences,Northeast Forestry University,Harbin 150040;2.MabCom Inc.,Daqing 163316;China |
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| Abstract: | As a biomarker of diagnosis in liver cancer,alpha-fetoprotein(AFP) has been highlighted recently.And many studies addressed AFP-derived peptides as immunologic responders in hepatocellular carcinoma and their uses in the study and generation of AFP-peptide sensitized T cells directed against hepatoma cells.The roles of AFP-derived peptide epitopes to T cell activities during the course of hepatoma immunotherapies were fur ther discussed. |
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| Keywords: | alpha-fetoprotein derived peptides epitopes hepatocellular carcinoma immunotherapy |
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