| S-100B蛋白在新生儿缺氧缺血性脑病中的临床应用进展 |
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| 引用本文： | 柳和华,李芳君.S-100B蛋白在新生儿缺氧缺血性脑病中的临床应用进展[J].现代生物医学进展,2010,10(3). |
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| 作者姓名： | 柳和华 李芳君 |
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| 作者单位： | 1. 石河子大学医学院,新疆,石河子,832000
2. 石河子大学医学院,新疆,石河子,832000;石河子大学医学院第一附属医院,新疆,石河子,832000 |
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| 摘 要： | S-100B蛋白是一类钙离子结合蛋白,由神经系统胶质细胞分泌,广泛分布于神经组织中。在正常情况下发挥重要的生理作用,但分泌过高具有神经毒性。血清中S-100B蛋白含量与新生儿缺氧缺血性脑病(HIE)呈正相关,可作为早期诊断HIE脑损伤及判断损伤程度及预后的有效指标。通过动态监测S-100B蛋白含量,了解脑损伤后血清中S-100B蛋白水平变化的时间规律性,S-100B蛋白可作为脑损伤后神经生化新标志物。本文对血清S-100B蛋白在新生儿缺氧缺血性脑病诊断中的价值作一综述。
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| 关 键 词： | 缺氧缺血性脑病 新生儿 S-100B蛋白 |
Clinical Application of S-100B protein in Neonatal hypoxic-ischemic encephalopathy |
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| LIU He-hua,LI Fang-jun.Clinical Application of S-100B protein in Neonatal hypoxic-ischemic encephalopathy[J].Progress in Modern Biomedicine,2010,10(3). |
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| Authors: | LIU He-hua LI Fang-jun |
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| Institution: | LIU He-hua1,LI Fang-jun2 (1Medical College of Shihezi Unverisity,Shihezi 832000,China,2The First Affiliated Hospital of Shihezi Unverisity,China) |
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| Abstract: | S-100B is one kind of the calcium binding proteins.As growth factor of neuraxon,it is excreted by neuroglial cell,and distributing in nerve tissue extensively.Although S-100B has very important values neurophysiological,it has neurotoxicity with excessive excreting.There was significant relation between S-100B protein of blood serum and Neonate Hypoxic-ischemic Encephalopathy in newborn infants.S-100B protein of blood serum is an useful method for diagnosis and assessment prognosis of HIE. Investigating the... |
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| Keywords: | Hypoxic-ischemic Encephalopathy(HIE) Neonate S-100B protein |
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