Recurrent adenylation domain replacement in the microcystin synthetase gene cluster期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Recurrent adenylation domain replacement in the microcystin synthetase gene cluster

Authors:	David P Fewer Leo Rouhiainen Jouni Jokela Matti Wahlsten Kati Laakso Hao Wang Kaarina Sivonen

Institution:	(1) Department of Applied Chemistry and Microbiology, University of Helsinki, PO Box 56, Viikki Biocenter, Viikinkaari 9, FIN-00014, Finland;(2) Valio Ltd, R&D, PO Box 30, FIN-00039 Valio, Helsinki, Finland

Abstract:	Background Microcystins are small cyclic heptapeptide toxins produced by a range of distantly related cyanobacteria. Microcystins are synthesized on large NRPS-PKS enzyme complexes. Many structural variants of microcystins are produced simulatenously. A recombination event between the first module of mcyB (mcyB1) and mcyC in the microcystin synthetase gene cluster is linked to the simultaneous production of microcystin variants in strains of the genus Microcystis.

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