Glycogen synthase kinase 3α and 3β have distinct functions during cardiogenesis of zebrafish embryo |
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| Authors: | Huang-Chieh Lee Jen-Ning Tsai Pei-Yin Liao Wei-Yuan Tsai Kai-Yen Lin Chung-Cheng Chuang Chi-Kuang Sun Wen-Chang Chang Huai-Jen Tsai |
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| Institution: | (1) Institute of Molecular and Cellular Biology, National Taiwan University, NO. 1, Roosevelt Road, Sec. 4, 106 Taipei, Taiwan;(2) School of Medical Laboratory and Biotechnology, Chung Shan Medical University, 402 Taichung, Taiwan;(3) Graduate Institute of Photonics and Optoelectronics and Department of Electrical Engineering, National Taiwan University and Research Center for Applied Sciences, Academia Sinica, 10617 Taipei, Taiwan;(4) Institute of Biochemical Sciences, National Taiwan University, 106 Taipei, Taiwan;(5) Institute of Biological Chemistry, Academia Sinica, 115 Nankang, Taiwan |
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| Abstract: | Background Glycogen synthase kinase 3 (GSK3) encodes a serine/threonine protein kinase, is known to play roles in many biological processes.
Two closely related GSK3 isoforms encoded by distinct genes: GSK3α (51 kDa) and GSK3β (47 kDa). In previously studies, most
GSK3 inhibitors are not only inhibiting GSK3, but are also affecting many other kinases. In addition, because of highly similarity
in amino acid sequence between GSK3α and GSK3β, making it difficult to identify an inhibitor that can be selective against
GSK3α or GSK3β. Thus, it is relatively difficult to address the functions of GSK3 isoforms during embryogenesis. At this study,
we attempt to specifically inhibit either GSK3α or GSK3β and uncover the isoform-specific roles that GSK3 plays during cardiogenesis. |
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