FlexOracle: predicting flexible hinges by identification of stable domains |
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| Authors: | Samuel C Flores Mark B Gerstein |
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| Institution: | (1) Department of Physics, Yale University, Bass 432, 266 Whitney Ave, New Haven, CT 06520, USA;(2) Department of Molecular Biophysics and Biochemistry, Yale University, Bass 432, 266 Whitney Ave., New Haven, CT 06520, USA;(3) Department of Computer Science, Yale University, Bass 432, 266 Whitney Ave., New Haven, CT 06520, USA;(4) Department of Computer Science, Yale University, Bass 432, 266 Whitney Ave., New Haven, CT 06520, USA |
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| Abstract: | Background Protein motions play an essential role in catalysis and protein-ligand interactions, but are difficult to observe directly.
A substantial fraction of protein motions involve hinge bending. For these proteins, the accurate identification of flexible
hinges connecting rigid domains would provide significant insight into motion. Programs such as GNM and FIRST have made global
flexibility predictions available at low computational cost, but are not designed specifically for finding hinge points. |
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