Evolution favors protein mutational robustness in sufficiently large populations |
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| Authors: | Jesse D Bloom Zhongyi Lu David Chen Alpan Raval Ophelia S Venturelli Frances H Arnold |
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| Affiliation: | (1) Division of Chemistry and Chemical Engineering, California Institute of Technology, 91125 Pasadena, California, USA;(2) Keck Graduate Institute of Applied Life Sciences and School of Mathematical Sciences, Claremont Graduate University, 91711 Claremont, CA, USA |
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| Abstract: | Background An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influence the course of future evolution. Functionally similar proteins can differ substantially in their robustness to mutations and capacity to evolve new functions, but it has remained unclear whether any of these differences might be due to evolutionary selection for these properties. |
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