The stochastic behavior of a molecular switching circuit with feedback |
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| Authors: | Supriya Krishnamurthy Eric Smith David Krakauer Walter Fontana |
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| Institution: | (1) Swedish Institute of Computer Science, Box 1263, SE-164 29 Kista, Sweden;(2) Department of Information Technology and Communication, KTH – Royal Institute of Technology, SE-164 40 Kista, Sweden;(3) Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA;(4) Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA |
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| Abstract: | Background Using a statistical physics approach, we study the stochastic switching behavior of a model circuit of multisite phosphorylation
and dephosphorylation with feedback. The circuit consists of a kinase and phosphatase acting on multiple sites of a substrate
that, contingent on its modification state, catalyzes its own phosphorylation and, in a symmetric scenario, dephosphorylation.
The symmetric case is viewed as a cartoon of conflicting feedback that could result from antagonistic pathways impinging on
the state of a shared component. |
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