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The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor |
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| Authors: | Marcel Winnig Bernd Bufe Nicole A Kratochwil Jay P Slack Wolfgang Meyerhof |
| Affiliation: | (1) German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Molecular Genetics, Arthur-Scheunert Allee 114-116, 14558 Nuthetal, Germany;(2) Pharmaceuticals Division, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland;(3) Givaudan Flavors Corporation, 1199 Edison Drive, Cincinnati, 45216, Ohio, USA;(4) Axxam, San Raffaele Biomedical Science Park, via Olgettina 58, 20132 Milan, Italy;(5) Department of Physiology, University of Saarland School of Medicine, 66421 Homburg/Saar, Germany |
| Abstract: | BackgroundDifferences in sweet taste perception among species depend on structural variations of the sweet taste receptor. The commercially used isovanillyl sweetener neohesperidin dihydrochalcone activates the human but not the rat sweet receptor TAS1R2+TAS1R3. Analysis of interspecies combinations and chimeras of rat and human TAS1R2+TAS1R3 suggested that the heptahelical domain of human TAS1R3 is crucial for the activation of the sweet receptor by neohesperidin dihydrochalcone. |
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