|
|||||
|
|
HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR |
|
| Authors: | Zachary Klase Prachee Kale Rafael Winograd Madhur V Gupta Mohammad Heydarian Reem Berro Timothy McCaffrey Fatah Kashanchi |
| Institution: | (1) Immunology, Microbiology and Tropical Medicine program, The George Washington University School of Medicine, Washington, District of Columbia 20037, USA;(2) Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington, District of Columbia 20037, USA;(3) Genetics program, The George Washington University School of Medicine, Washington, District of Columbia 20037, USA;(4) The Institute for Genomic Research, TIGR, Rockville, Maryland, 20850, USA |
| Abstract: | BackgroundRNA interference (RNAi) is a regulatory mechanism conserved in higher eukaryotes. The RNAi pathway generates small interfering RNA (siRNA) or micro RNA (miRNA) from either long double stranded stretches of RNA or RNA hairpins, respectively. The siRNA or miRNA then guides an effector complex to a homologous sequence of mRNA and regulates suppression of gene expression through one of several mechanisms. The suppression of gene expression through these mechanisms serves to regulate endogenous gene expression and protect the cell from foreign nucleic acids. There is growing evidence that many viruses have developed in the context of RNAi and express either a suppressor of RNAi or their own viral miRNA. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |