On the origin of the histone fold |
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Authors: | Vikram Alva Moritz Ammelburg Johannes Söding Andrei N Lupas |
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Institution: | 1.Department of Protein Evolution,Max-Planck-Institute for Developmental Biology,Tübingen,Germany |
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Abstract: | Background Histones organize the genomic DNA of eukaryotes into chromatin. The four core histone subunits consist of two consecutive
helix-strand-helix motifs and are interleaved into heterodimers with a unique fold. We have searched for the evolutionary
origin of this fold using sequence and structure comparisons, based on the hypothesis that folded proteins evolved by combination
of an ancestral set of peptides, the antecedent domain segments. |
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