Characterization of a novel bifunctional mutant of staphylokinase with platelet-targeted thrombolysis and antiplatelet aggregation activities |
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| Authors: | Hongshan Chen Wei Mo Huabo Su Yanling Zhang Houyan Song |
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| Institution: | (1) The Key Laboratory of Molecular Medicine, Ministry of Education, Fudan university, Dong' an Road 130#, Shanghai, 200032, P. R. China;(2) Department of Biochemistry and Molecular Biology, Medical College, Nan Tong University, Qi xiu Road 19#, Nantong, 226001, P. R. China |
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| Abstract: | Background Although staphylokianse (SAK) is among the most promising blood dissolving agents, it is far from ideal. It is interesting
to hypothesize that the clot lysis efficacy of SAK can be enhanced with direct active platelet binding ability, and at the
same time the rethrombosis complication after successful recanalization can be minimized with an antiplatelet aggregation
activity. The present study was performed to characterize the functional properties of RGD-SAK, a novel mutant of staphylokinase
(SAK). |
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