Metabotropic Glutamate Receptors Stimulate Phospholipase D via Different Pathways in the Adult and Neonate Rat Hippocampus |
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Authors: | Attucci Sabina Albani-Torregrossa Serenella Moroni Flavio Pellegrini-Giampietro Domenico E. |
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Affiliation: | (1) Dipartimento di Farmacologia Preclinica e Clinica, Universitè di Firenze, Viale Pieraccini 6, 50139 Firenze, Italy |
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Abstract: | In order to characterize the ontogenetic profile of metabotropic glutamate (mGlu) receptors coupled to phospholipase D (PLD) we examined the effects of selected mGlu agents on PLD activity in immature and adult rat hippocampus. The group I mGlu receptor agonist 3,5-dihydroxyphenylglycine stimulated PLD in immature tissue, but reduced the PLD response evoked by the nonselective mGlu receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate [(1S,3R)-ACPD] in adult hippocampus. (2R,1S,2R,3S)-2-(2-Carboxy-3-phenylcyclopropyl)glycine (PCCG-13), a recently characterized selective antagonist of PLD-coupled mGlu receptors, displayed a much greater activity in reducing the PLD response to (1S,3R)-ACPD in adult than in neonate hippocampus. Our results lend support to the hypothesis that glutamatergic activation of PLD in the rat hippocampus is developmentally regulated. |
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Keywords: | Metabotropic glutamate receptors phospholipase D ontogeny PCCG-13 rat hippocampus |
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