Evaluation of potential interactions between the metastasis-associated protein S100A4 and the tumor suppressor protein p53 |
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Authors: | Gisle Berge Gunhild M Mælandsmo |
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Institution: | (1) Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway |
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Abstract: | Metastasis is a complex cascade of events involving a finely tuned interplay between malignant cells and multiple host factors.
The transition from benign tumor growth to malignancy is manifested by the ability of tumor cells to traverse tissue barriers
and invade surrounding tissues. Among a multitude of factors playing a role, the small calcium-binding protein S100A4 has
been found to add to the invasive and metastatic capacity of cancer cells. However, the exact molecular function or mechanism
by which S100A4 exerts its putative metastasis-promoting effects has not been fully elucidated, and the protein is most likely
involved in several aspects of tumor progression. Several studies have recently described a direct interaction and/or reciprocal
influence between S100A4 and the tumor suppressor protein p53. This corresponds to reports linking p53 to other S100-family
members, especially S100B. The consequences are intriguing, connecting the metastasis-promoting protein S100A4 to the large
set of important p53-mediated functions, with broad potential importance in cancer development and metastasis. In this review
we emphasize the studies involving p53 and S100A4, elucidating and comparing reported results and conclusions. |
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