Plasma clearance of cholic acid in patients with chronic diseases of the liver |
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| Authors: | W Medrzejewski A Habior B Samociuk-Medrzejewska M Cwik?a |
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| Affiliation: | Kliniki Gastroenterologii i Przemiany Materii CMKP w Warszawie. |
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| Abstract: | The diagnostic value of 14C-cholic acid plasma clearance following oral administration was evaluated. 14C-cholic acid clearance was 1223 +/- 267 mL/min. per 1 square meter in the control group without liver disease. Significantly lower values (p less than 0.001) were obtained in the patients with chronic hepatitis (694 +/- 137 mL/min. per 1 square meter) and liver cirrhosis (332 +/- 156 mL/min. per 1 square meter). Sensitivity of the 14C-cholic acid clearance test was 100% while specificity--80%. A 3-year follow-up has shown that this test is of high prognostic value in patients with liver cirrhosis. |
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