| Institution: | (1) Instituto Universitario de Investigación en Nanociencia de Aragón (INA), Universidad de Zaragoza, Edif. Inter. II, 50009 Zaragoza, Spain;(2) Instituto de Ciencia de Materiales de Aragón (ICMA), Universidad de Zaragoza-CSIC, Facultad de Ciencias, 50009 Zaragoza, Spain;(3) Hospital Clínico Universitario “Lozano Blesa”, Avda Gomez Laguna, 50009 Zaragoza, Spain;(4) Serveis Cientificotécnics (SCT), Universitat de Barcelona, Calle Lluis Sole i Sabaris, 1-3, 08028 Barcelona, Spain |
| Abstract: | Bioferrofluids obtained from carbon coated iron nanoparticles are promising candidates for magnetic drug delivery. The carbon
cages render the particles biocompatible, and provide a good support for drug adsorption. We propose a method in which gold
plated permanent magnets are implanted directly in the affected organ, close to the tumour, by endoscopic techniques. The
bioferrofluid charged with the chemotherapeutic agent is injected and the particles attracted to the magnet, then desorption
of the drug takes place at the tumoral region. This method seems to be more promising, costless and effective than that based
on the application of external magnetic fields. Preliminary results of drug adsorption and a preclinical experimental animal
model are described. |
