Cilastatin-sensitive dehydropeptidase I enzymes from three sources all catalyze carbapenem hydrolysis and conversion of leukotriene D4 to leukotriene E4 |
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| Authors: | C A Farrell N J Allegretto M J Hitchcock |
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| Institution: | 1. State Key Laboratory of Chemical Resource Engineering, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China;2. Jinghuan Textile Recycling Handan Co., Ltd, Handan 056002, China;1. Department of Vascular and Interventional Radiology, François-Mitterrand Teaching Hospital, University of Bourgogne-Franche-Comté, 14 Rue Gaffarel, BP 77908, 21079 Dijon, France;2. Department of Epidemiology and Biostatistics, François-Mitterrand Teaching Hospital, University of Bourgogne-Franche-Comté, 14 Rue Gaffarel, BP 77908, 21079 Dijon, France;3. Department of Medical Intensive Care, François-Mitterrand Teaching Hospital, University of Bourgogne-Franche-Comté, 14 Rue Gaffarel, BP 77908, 21079 Dijon, France;1. Department of Pharmaceutics, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China;2. School of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia 750004, China;3. Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine & Key Lab of Hui Ethnic Medicine Modernization, Ministry of Education, Yinchuan, Ningxia 750004, China;4. Departments of Biomedical Engineering and Pharmaceutics, Purdue University, West Lafayette, IN 47907, USA;1. Department of Radiology, Wakayama Medical University, Wakayama, Japan;2. Department of Human Pathology, Wakayama Medical University, Wakayama, Japan |
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| Abstract: | The dipeptidase, dehydropeptidase I (EC 3.4.13.11), was purified to homogeneity from rat lung, rat kidney, and hog kidney. Analysis of physical parameters (subunit molecular weights, Km values for glycyldehydrophenylalanine, Ki values for dehydropeptidase I inhibitors, and immunoreactivity) showed the rat dipeptidases to be similar to each other but different from the hog dipeptidase. However, all three enzymes hydrolyzed imipenem and converted leukotriene D4 to leukotriene E4, and these activities were inhibited by cilastatin. |
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